Description

Objectives in terms of knowledge (course content) :

• Basic notions of organic chemistry : chirality, Lewis structure, acide/base theories, nucleophile/electrophile, chemical mechanisms.
• Enzymes and enzymatic chemistry : tridimensionnal structure, kinetic and thermodynamic aspects, active site, structures and chemical properties of coenzymes.
• Mecanistic aspects of the main metabolic conversions.
• Comparison with experimental organic chemistry : saponification, amide hydrolysis, esterification/thioesterification/amide formation, oxidation/reduction, amination/deamination, carbone-carbone bond creation, fragmentation, isomerization/epimerization.
• Metals in the chemistry of life : examples or iron and molybdenum

Compétences visées

Objectives in terms of skills :

• Acquisition of capacities to analyze the chemical mechanisms taking place during enzymatic and metabolic transformations.
• Understanding of enzymatic mechanisms involved in suicide inhibition.

Bibliographie

Bibliography:

• Chimie Organique des Processus Biologiques, McMurry, Begley et Mislin, Eds De Boeck
• The Organic Chemistry of Biological Pathways, McMurry and Begley, Roberts and Cie Eds
• Classics in total synthesis, Nicolaou and Sorensen, Wiley VCH Eds.
• Mécanismes réactionnels en chimie organique, Brückner, Eds De Boeck

Contacts

Responsable(s) de l'enseignement

• Vladimir Torbeev

MCC

Les épreuves indiquées respectent et appliquent le règlement de votre formation, disponible dans l'onglet Documents de la description de la formation.

Régime d'évaluation

CT (Contrôle terminal, mêlé de contrôle continu)

Coefficient

0.5

Évaluation initiale / Session principale - Épreuves

Seconde chance / Session de rattrapage - Épreuves