Comparative and medical genomics

  • Cours (CM) 14h
  • Cours intégrés (CI) -
  • Travaux dirigés (TD) 12h
  • Travaux pratiques (TP) -
  • Travail étudiant (TE) -

Description du contenu de l'enseignement

Objectives in terms of knowledge (course content) :
  • Basic concepts and methodologies used in comparative genomics (orthology, paralogy, synteny, evolutionary rates…)
  • Evolution of prokaryotic and eukaryotic genomes (mechanisms and evolutionary trends)
  • Applied Comparative Genomics: phylogenetic footprinting, phylogenetic profiles, prediction of functional links, identification of targets by genotype/phenotype correlations…
  • Population genomics
  • Personal and medical genomics: variations and polymorphism, types of personal genomic data, detection and prioritization of variants, examples of large-scale projects

Compétences à acquérir

Objectives in terms of acquired skills :

Mastery of main internet resources dedicated to comparative genomics
Ability to mobilize multidisciplinary knowledge
Ability to develop an integrative strategy to answer a complex biological problem
Ability to analyse personal NGS data to identify variants (quality, mapping, variant calling)
Ability to prioritize candidates to identify disease–causing variants
Capacity for a critical analysis of high-throughput data
Awareness of ethical issues raised by patient data

Contact

Ecole Supérieure de Biotechnologie de Strasbourg

300 BOULEVARD SEBASTIEN BRANT
67412 ILLKIRCH-GRAFFENSTADEN
0368854510

Intervenants


MASTER - Biotechnologies