Comparative and medical genomics
- Cours (CM) 14h
- Cours intégrés (CI) -
- Travaux dirigés (TD) 12h
- Travaux pratiques (TP) -
- Travail étudiant (TE) -
Langue de l'enseignement : Anglais
Description du contenu de l'enseignement
Objectives in terms of knowledge (course content) :
- Basic concepts and methodologies used in comparative genomics (orthology, paralogy, synteny, evolutionary rates…)
- Evolution of prokaryotic and eukaryotic genomes (mechanisms and evolutionary trends)
- Applied Comparative Genomics: phylogenetic footprinting, phylogenetic profiles, prediction of functional links, identification of targets by genotype/phenotype correlations…
- Population genomics
- Personal and medical genomics: variations and polymorphism, types of personal genomic data, detection and prioritization of variants, examples of large-scale projects
Compétences à acquérir
Objectives in terms of acquired skills :
Mastery of main internet resources dedicated to comparative genomics
Ability to mobilize multidisciplinary knowledge
Ability to develop an integrative strategy to answer a complex biological problem
Ability to analyse personal NGS data to identify variants (quality, mapping, variant calling)
Ability to prioritize candidates to identify disease–causing variants
Capacity for a critical analysis of high-throughput data
Awareness of ethical issues raised by patient data
Mastery of main internet resources dedicated to comparative genomics
Ability to mobilize multidisciplinary knowledge
Ability to develop an integrative strategy to answer a complex biological problem
Ability to analyse personal NGS data to identify variants (quality, mapping, variant calling)
Ability to prioritize candidates to identify disease–causing variants
Capacity for a critical analysis of high-throughput data
Awareness of ethical issues raised by patient data
Contact
Ecole Supérieure de Biotechnologie de Strasbourg
300 BOULEVARD SEBASTIEN BRANT67412 ILLKIRCH-GRAFFENSTADEN
0368854510
esbs-scolarite@unistra.fr
Intervenants
Odile Lecompte